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Article

ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes

18 Aug 2006

Abstract excerpt

BACKGROUND: Co-factor ACTR is frequently overexpressed and/or amplified in multiple types of tumors. The mechanism of its function in prostate cancer (CaP) is still unclear. METHODS: The effects of ACTR and androgen receptor (AR) depletion on cell proliferation and gene expression and their functions were analyzed in a panel of androgen-dependent and -independent CaP cells and CWR22 xenograft. RESULTS: ACTR and...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 16921507
DOI: 10.1002/pros.20477

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