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Article

Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.

Structure (London, England : 1993) - 1 Aug 2007

Gabelli Sandra B, Bianchet Mario A, Xu WenLian, Dunn Christopher A, Niu Zhi-Dian, Amzel L Mario, Bessman Maurice J

Abstract excerpt

Nudix hydrolases are a superfamily of pyrophosphatases, most of which are involved in clearing the cell of potentially deleterious metabolites and in preventing the accumulation of metabolic intermediates. We determined that the product of the orf17 gene of Escherichia coli, a Nudix NTP hydrolase, catalyzes the hydrolytic release of pyrophosphate from dihydroneopterin triphosphate, the committed step of folate...

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Identifiers

PMID: 17698004
DOI: 10.1016/j.str.2007.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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