Article
Sjögren's syndrome--a plethora of clinical and immunological phenotypes with a complex genetic background.
Annals of the New York Academy of Sciences - 1 Jun 2007
Jonsson Roland, Bolstad Anne Isine, Brokstad Karl A, Brun Johan G
Abstract excerpt
Primary Sjögren's syndrome is a complex autoimmune disorder, considered to represent an ideal disease with which to study the mechanisms underlying autoimmunity because its manifestations are both organ specific and systemic in nature. The characteristic histologic finding in target organs is a progressive focal infiltration of mononuclear lymphoid cells, replacing glandular epithelium (lymphoepithelial lesion)....
Topics
- Animals
- Autoantibodies
- B-Lymphocytes
- Cytokines
- Gene Expression
- Gene Expression Profiling
- Humans
- Phenotype
- Prognosis
- Sjogren's Syndrome