Article
Immunohistochemical and mutational analysis of FLASH in gastric carcinomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Aug 2007
Jeong Eun Goo, Lee Sung Hak, Lee Hae Woo, Soung Young Hwa, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
FLASH was initially identified as a pro-apoptotic protein that transmits an apoptosis signal during death receptor-induced apoptosis. Additionally, diverse biologic roles of FLASH, including TNF-induced NF-kappaB activation, cell-cycle progression and cell division, have been identified. Although such functions are important in cancer pathogenesis, little is known about the alterations of FLASH gene and FLASH...
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