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Article

c-FLIP is a target of the E3 ligase deltex1 in gastric cancer

26 Jan 2018

Abstract excerpt

Abstract The ubiquitin E3 ligase DELTEX1 (DTX1) is specifically downregulated in gastric cancer tissues, and expression of DTX1 is linked to better prognoses and survival in gastric cancer. Cellular FLICE inhibitory protein (c-FLIP) is known for its pivotal role in the resistance of cancer cells to death receptor-induced cell death. Here, we show that DTX1 is an E3 ligase for c-FLIP in gastric cancer cells. DTX1...

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PMID: 29374180
DOI: 10.1038/s41419-017-0165-6

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