Article
Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia.
The Tohoku journal of experimental medicine - 1 Mar 2002
Sasaki Osam, Meguro Kuniaki, Tohmiya Yasuo, Funato Tadao, Shibahara Shigeki, Sasaki Takeshi
Abstract excerpt
The retinoblastoma protein-interacting zinc finger gene (RIZ) is a zinc-finger type DNA binding protein and is postulated as a member of the nuclear protein-methyltransferase superfamily. RIZ gene encodes for two proteins, RIZ1 and RIZ2. While RIZ1 contains the N-terminal PR (PRDI-BF1 and RIZ homologous)-domain, RIZ2 lacks it. RIZ1 is now considered as a tumor suppressor. We analyzed nucleotide alteration of RIZ...
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