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Article

Inactivation of a histone methyltransferase by mutations in human cancers.

Cancer research - 15 Nov 2003

Kim Keun-Cheol, Geng Liqing, Huang Shi

Abstract excerpt

Histone methyltransferase (HMT)(1) class enzymes that methylate lysine residues of histones or proteins contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. Intact PR or SET sequence is required for tumor suppression functions, but it remains unclear whether it is histone methyltransferase activity that underlies...

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Source

Identifiers

PMID: 14633678

Genes

SET
PRDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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