Article
A multidimensional analysis of genes mutated in breast and colorectal cancers.
Genome research - 1 Sept 2007
Lin Jimmy, Gan Christine M, Zhang Xiaosong, Jones Siân, Sjöblom Tobias, Wood Laura D, Parsons D Williams, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Parmigiani Giovanni, Velculescu Victor E
Abstract excerpt
A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and...
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