The consensus coding sequences of human breast and colorectal cancers.

doi:10.1126/science.1133427

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Article

The consensus coding sequences of human breast and colorectal cancers.

Science (New York, N.Y.) - 13 Oct 2006

Sjöblom Tobias, Jones Siân, Wood Laura D, Parsons D Williams, Lin Jimmy, Barber Thomas D, Mandelker Diana, Leary Rebecca J, Ptak Janine, Silliman Natalie, Szabo Steve, Buckhaults Phillip, Farrell Christopher, Meeh Paul, Markowitz Sanford D, Willis Joseph, Dawson Dawn, Willson James K V, Gazdar Adi F, Hartigan James, Wu Leo, Liu Changsheng, Parmigiani Giovanni, Park Ben Ho, Bachman Kurtis E, Papadopoulos Nickolas, Vogelstein Bert, Kinzler Kenneth W, Velculescu Victor E

Abstract excerpt

The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of...

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PMID: 16959974
DOI: 10.1126/science.1133427

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