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Article

Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement.

European journal of medicinal chemistry - 1 May 2008

Frey Virginie, Viaud Julien, Subra Guy, Cauquil Nicolas, Guichou Jean-François, Casara Patrick, Grassy Gérard, Chavanieu Alain

Abstract excerpt

To study the structure-activity relationships (SAR) and the binding activity of pro-apoptotic Bak BH3 domain, we synthesised several 16mer peptide analogues corresponding to the region (72)-GQVGRQLAIIGDDINR-(87). Using different amino acids varying in length, steric and electronic properties, we investigated the role and the nature of physicochemical parameters of residues Val74, Leu78, Ile81 and Ile85,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17692431
DOI: 10.1016/j.ejmech.2007.06.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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