Article
Structural and biophysical characterization of XIAP BIR3 G306E mutant: insights in protein dynamics and application for fragment-based drug design.
Chemical biology & drug design - 1 Sept 2009
Moore Cathy D, Wu Haihong, Bolaños Ben, Bergqvist Simon, Brooun Alexei, Pauly Tom, Nowlin Dawn
Abstract excerpt
Previous reports describe modulators of X-linked inhibitor of apoptosis (XIAP)-caspase interaction designed from the AVPI N-terminal peptide sequence of second mitochondria-derived activator of caspase. A fragment-based drug design strategy was initiated to identify therapeutic non-peptidomimetic antagonists of X-linked inhibitor of apoptosis protein-protein interactions. Fragments that bind to the AVPI binding...
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