Article
Identification and validation of biomarkers of IgV(H) mutation status in chronic lymphocytic leukemia using microfluidics quantitative real-time polymerase chain reaction technology.
The Journal of molecular diagnostics : JMD - 1 Sept 2007
Abruzzo Lynne V, Barron Lynn L, Anderson Keith, Newman Rachel J, Wierda William G, O'brien Susan, Ferrajoli Alessandra, Luthra Madan, Talwalkar Sameer, Luthra Rajyalakshmi, Jones Dan, Keating Michael J, Coombes Kevin R
Abstract excerpt
To develop a model incorporating relevant prognostic biomarkers for untreated chronic lymphocytic leukemia patients, we re-analyzed the raw data from four published gene expression profiling studies. We selected 88 candidate biomarkers linked to immunoglobulin heavy-chain variable region gene (IgV(H)) mutation status and produced a reliable and reproducible microfluidics quantitative real-time polymerase chain...
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