Article
Immunoglobulin mutational status detected through single-round amplification of partial V(H) region represents a good prognostic marker for clinical outcome in chronic lymphocytic leukemia.
The Journal of molecular diagnostics : JMD - 1 Nov 2005
Marasca Roberto, Maffei Rossana, Morselli Monica, Zucchini Patrizia, Castelli Ilaria, Martinelli Silvia, Fontana Marcella, Ravanetti Sara, Curotti Monica, Leonardi Giovanna, Cagossi Katia, Partesotti Giovanni, Torelli Giuseppe
Abstract excerpt
The immunoglobulin (Ig) mutational status in B-cell chronic lymphocytic leukemia (CLL) distinguishes two subsets of patients with different prognosis. Ig status detection is commonly performed with a panel of V(H) family-specific primers. Although this method detects clonal VDJ rearrangement in virtually all cases, it is technically cumbersome and therefore not widely used clinically. Here, we describe a simple...
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