Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGHV mutational status testing in chronic lymphocytic leukemia.

American journal of hematology - 1 Dec 2017

Crombie Jennifer, Davids Matthew S

Abstract excerpt

As the therapeutic landscape for chronic lymphocytic leukemia (CLL) continues to expand, biological predictors of response to therapy are becoming increasingly important. One such predictive biomarker is the mutational status of the variable region of the immunoglobulin heavy chain (IGHV) gene, which is a powerful predictor of duration of response and overall survival with chemoimmunotherapy (CIT). As this test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to DNA Mutational Analysis
Share to CIT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunotherapy

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 28589701
DOI: 10.1002/ajh.24808
PMCID: PMC5675754

Genes

CIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGHV mutational status testing in chronic lymphocytic leukemia.PMID 28589701Read ↗

The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatmentSemantic proximity Read ↗

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the 2022 update of the recommendations by ERIC, the European Research Initiative on CLLSemantic proximity Read ↗

Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement.Semantic proximity Read ↗

iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL.Semantic proximity Read ↗

Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencingSemantic proximity Read ↗

The challenge of unavailable IGH mutational status in CLL in resource-limited settings.Semantic proximity Read ↗

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

Clinical Outcomes in a Large Canadian Centralized CLL Clinic Based on Treatment and Molecular Factors over a Decade.Semantic proximity Read ↗

Chronic lymphocytic leukemia with mutated IgVH1-69 usage: a distinct CLL subgroup with more indolent behavior?Semantic proximity Read ↗

The Biology of Chronic Lymphocytic Leukemia: Diagnostic and Prognostic Implications.Semantic proximity Read ↗

Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upSemantic proximity Read ↗

Chronic lymphocytic leukemia in Oman: real-world outcomes, molecular testing gaps, and access to targeted therapy in a low- incidence settingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.