Analysis of Virus Population Profiles within Pigs Infected with Virulent Classical Swine Fever Viruses: Evidence for Bottlenecks in Transmission but Absence of Tissue-Specific Virus Variants.

doi:10.1128/JVI.01119-20

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Article

Analysis of Virus Population Profiles within Pigs Infected with Virulent Classical Swine Fever Viruses: Evidence for Bottlenecks in Transmission but Absence of Tissue-Specific Virus Variants.

Journal of virology - 15 Sept 2020

Johnston Camille Melissa, Fahnøe Ulrik, Lohse Louise, Bukh Jens, Belsham Graham J, Rasmussen Thomas Bruun

Abstract excerpt

Classical swine fever virus (CSFV) contains a specific motif within the E2 glycoprotein that differs between strains of different virulence. In the highly virulent CSFV strain Koslov, this motif comprises residues S763/L764 in the polyprotein. However, L763/P764 represent the predominant alleles in published CSFV genomes. In this study, changes were introduced into the CSFV strain Koslov (here called vKos_SL) to...

Topics

Animals
Cell Line
Classical Swine Fever
Classical Swine Fever Virus
DNA Viruses
DNA, Complementary
Genome, Viral
Glycoproteins
Haplotypes
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

RNA, Viral

Swine

Viral Envelope Proteins

Viremia

Virulence

Source

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Identifiers

PMID: 32699086
DOI: 10.1128/JVI.01119-20
PMCID: PMC7495388

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