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West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

9 Aug 2007

Abstract excerpt

West Nile virus (WNV)-mediated neuronal death is a hallmark of WNV meningitis and encephalitis. However, the mechanisms of WNV-induced neuronal damage are not well understood. We investigated WNV neuropathogenesis by using human neuroblastoma cells and primary rat hippocampal neurons. We observed that WNV activates multiple unfolded protein response (UPR) pathways, leading to transcriptional and translational...

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PMID: 17686866
DOI: 10.1128/jvi.01151-07

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