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Article

The role of the unfolded protein response in dengue virus pathogenesis

16 Feb 2017

Abstract excerpt

Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host-viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a prosurvival cellular reaction induced in response to DENV-mediated endoplasmic reticulum stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis,...

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PMID: 28207988
DOI: 10.1111/cmi.12734

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