Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.

Cancer research - 15 Mar 2010

Hoffmann Marion, Schirmer Markus A, Tzvetkov Mladen V, Kreuz Markus, Ziepert Marita, Wojnowski Leszek, Kube Dieter, Pfreundschuh Michael, Trümper Lorenz, Loeffler Markus, Brockmöller Jürgen

Abstract excerpt

NAD(P)H oxidase is a major endogenous source of reactive oxygen species (ROS). ROS may not only be involved in carcinogenesis but also in efficacy of chemotherapeutic agents like doxorubicin. By a comprehensive genotyping approach covering 48 genetic polymorphisms (single-nucleotide polymorphisms) in five subunits of phagocytic NAD(P)H oxidase, we asked whether they affect gene expression, enzymatic activity, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclophosphamide
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Etoposide

Share to Lymphoma, Non-Hodgkin

Share to NADPH Oxidases

Share to Prednisolone

Share to Protein Subunits

Share to Vincristine

Source

Identifiers

PMID: 20215507
DOI: 10.1158/0008-5472.CAN-09-2388

Genes

CYBA
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.PMID 20215507Read ↗

Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.Semantic proximity Read ↗

NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced CardiotoxicitySemantic proximity Read ↗

Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study.Semantic proximity Read ↗

CYBA as a Potential Biomarker for Renal Cell Carcinoma: Evidence from an Integrated Genetic Analysis.Semantic proximity Read ↗

Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.Semantic proximity Read ↗

Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.Semantic proximity Read ↗

Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma.Semantic proximity Read ↗

Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21.Semantic proximity Read ↗

Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma.Semantic proximity Read ↗

Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.Semantic proximity Read ↗

Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4: functional implications.Semantic proximity Read ↗

CYBA encoding p22(phox), the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.