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Article

TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability.

Journal of molecular biology - 21 Sept 2007

Hieb Aaron R, Halsey Wayne A, Betterton Meredith D, Perkins Thomas T, Kugel Jennifer F, Goodrich James A

Abstract excerpt

Eukaryotic mRNA transcription by RNA polymerase II is a highly regulated complex reaction involving numerous proteins. In order to control tissue and promoter specific gene expression, transcription factors must work in concert with each other and with the promoter DNA to form the proper architecture to activate the gene of interest. The TATA binding protein (TBP) binds to TATA boxes in core promoters and bends...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17681538
DOI: 10.1016/j.jmb.2007.06.061

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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