Article
[Prognosis of affinity change of the TATA-binding protein to TATA-boxes upon polymorphisms of the human gene promoter TATA boxes].
Molekuliarnaia biologiia - 1 Jan 2000
Ponomarenko P M, Ponomarenko M P, Drachkova I A, Lysova M V, Arshinova T V, Savinkova L K, Kolchanov N A
Abstract excerpt
TATA-binding protein (TBP) is a subunit of basal transcription factor TFIID that recognizes and binds to the TATA-box on TATA-containing promoters of class II genes, and starts assembling RNA polymerase II basal transcription complex. It is shown in many works that the sequence of TATA-box with its flanking regions affects the level of basal and activated transcription. TATA-box polymorphisms and human hereditary...
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