Article
An experimental verification of the predicted effects of promoter TATA-box polymorphisms associated with human diseases on interactions between the TATA boxes and TATA-binding protein.
PloS one - 1 Jan 2013
Savinkova Ludmila, Drachkova Irina, Arshinova Tatyana, Ponomarenko Petr, Ponomarenko Mikhail, Kolchanov Nikolay
Abstract excerpt
Human genome sequencing has resulted in a great body of data, including a stunningly large number of single nucleotide polymorphisms (SNPs) with unknown phenotypic manifestations. Identification and comprehensive analysis of regulatory SNPs in human gene promoters will help quantify the effects of these SNPs on human health. Based on our experimental and computer-aided study of SNPs in TATA boxes and the use of...
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