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Article

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Gastroenterology - 1 Aug 2007

Mori-Akiyama Yuko, van den Born Maaike, van Es Johan H, Hamilton Stanley R, Adams Henry P, Zhang Jiexin, Clevers Hans, de Crombrugghe Benoit

Abstract excerpt

BACKGROUND AND AIMS: The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages. In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling. METHODS: To examine the function of SOX9 in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by generating mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17681175
DOI: 10.1053/j.gastro.2007.05.020

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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