Article
Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding.
Pharmacogenetics and genomics - 1 Jan 2008
Blanco Gerardo, Martínez Carmen, Ladero Jose M, Garcia-Martin Elena, Taxonera Carlos, Gamito Francisco G, Diaz-Rubio Manuel, Agundez Jose A G
Abstract excerpt
OBJECTIVES: To analyze whether gene variants leading to impaired drug metabolism are related with acute gastrointestinal bleeding after nonsteroidal anti-inflammatory drugs (NSAID) use. METHODS: Common CYP2C8 and CYP2C9 polymorphisms were studied in a cross-sectional study, involving 134 NSAID-re...
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