Article
An update on the pharmacogenomics of NSAID metabolism and the risk of gastrointestinal bleeding.
Expert opinion on drug metabolism & toxicology - 1 Apr 2020
Macías Yolanda, Gómez Tabales Javier, García-Martín Elena, Agúndez José A G
Abstract excerpt
Introduction: Several reports suggest a possible association between polymorphisms in the cytochrome P450 2C9 (CYP2C9) gene and the risk for non-steroidal anti-inflammatory drug (NSAID)-related adverse gastrointestinal events, including gastrointestinal bleeding. Because findings were controversial, a systematic review and a meta-analysis of eligible studies on this putative association was conducted.Areas...
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