Article
Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?
British journal of clinical pharmacology - 1 Jun 2001
Martin J H, Begg E J, Kennedy M A, Roberts R, Barclay M L
Abstract excerpt
AIMS: The aim of this study was to explore whether genetic variation of cytochrome P450 2C9 (CYP2C9) contributes to NSAID-associated gastric ulceration. The hypothesis tested was that CYP2C9 poor metabolizer genotype would predict higher risk of gastric ulceration in patients on NSAIDs that are metabolized by CYP2C9, due to higher plasma NSAID concentrations. METHODS: Peripheral blood DNA samples from 23 people...
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