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Article

Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use.

British journal of pharmacology - 1 Jan 2004

Martínez Carmen, Blanco Gerardo, Ladero José M, García-Martín Elena, Taxonera Carlos, Gamito Francisco G, Diaz-Rubio Manuel, Agúndez José A G

Abstract excerpt

Impaired drug metabolism is a major cause of adverse drug reactions, and it is often caused by mutations at genes coding for drug-metabolising enzymes. Two amino-acid polymorphisms of cytochrome P4502C9 (CYP2C9), an enzyme involved in the metabolism of several nonsteroidal anti-inflammatory drugs (NSAIDs), were studied in 94 individuals with acute bleeding after NSAIDs use and 124 individuals receiving NSAIDs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14707031
DOI: 10.1038/sj.bjp.0705623
PMCID: PMC1574205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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