Article
A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.
PLoS genetics - 1 Jul 2011
Ghabrial Amin S, Levi Boaz P, Krasnow Mark A
Abstract excerpt
Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that execute morphogenesis programs. Because such morphogenesis genes may function in many organs and developmental processes, mutations in them are expected to be pleiotropic and hence ignored or discarded in most standard genetic screens. Here we describe a...
Topics
- Animals
- Animals, Genetically Modified
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Genes, Insect
- Genes, Lethal
- Heterozygote
- Homozygote
- Morphogenesis
- Mutation