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Article

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.) - 1 Sept 2007

Nelson James E, Bhattacharya Renuka, Lindor Keith D, Chalasani Naga, Raaka Stuart, Heathcote E Jenny, Miskovsky Emil, Shaffer Eldon, Rulyak Stephen J, Kowdley Kris V

Abstract excerpt

UNLABELLED: Previous studies examining the relationship between HFE mutations and severity of nonalcoholic steatohepatitis (NASH) have been limited by small sample size or ascertainment bias. The aim of this study was to examine the relationship between HFE mutations and histological severity in...

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Source

Identifiers

PMID: 17680648
DOI: 10.1002/hep.21742

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17680648-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.PMID 17680648Read ↗

HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity.Semantic proximity Read ↗

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.Semantic proximity Read ↗

Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.Semantic proximity Read ↗

HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis.Semantic proximity Read ↗

HFE genotype in patients with hemochromatosis and other liver diseases.Semantic proximity Read ↗

Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls.Semantic proximity Read ↗

[HFE gene mutations, hepatic iron content, and histological severity in hepatitis C virus-induced chronic hepatitis].Semantic proximity Read ↗

Hfe mutations and iron overload in patients with alcoholic liver disease.Semantic proximity Read ↗

Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease.Semantic proximity Read ↗

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