Article
Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease.
Gut - 1 Aug 1998
Grove J, Daly A K, Burt A D, Guzail M, James O F, Bassendine M F, Day C P
Abstract excerpt
BACKGROUND: Iron overload is common in the livers of alcoholics and may play a role in disease pathogenesis. An MHC like gene, HFE, has recently been identified that is mutated in most patients with hereditary haemochromatosis (C282Y in 90% and H63D in 45% of the remainder). AIM: To examine the hypothesis that these mutations determine hepatic iron status in alcoholics and play a role in pre-disposition to...
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