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Article

HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity.

Hepatology (Baltimore, Md.) - 1 Jul 2002

Chitturi Shivakumar, Weltman Martin, Farrell Geoffrey C, McDonald David, Kench James, Liddle Christopher, Samarasinghe Dev, Lin Rita, Abeygunasekera Shehan, George Jacob

Abstract excerpt

There is conflicting evidence regarding inheritance of hemochromatosis gene (HFE) mutations and influence of hepatic iron deposition as cofactors for development of fibrosis in patients with nonalcoholic steatohepatitis (NASH). We studied hepatic iron content (Perls' stain grade), frequency of HFE mutations, and serum iron indices in 93 patients with NASH from a multiethnic background; 59 (63%) were of...

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Identifiers

PMID: 12085358
DOI: 10.1053/jhep.2002.33892

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity.PMID 12085358Read ↗

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.Semantic proximity Read ↗

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