Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls.

The American journal of gastroenterology - 1 Feb 2006

Gleeson Dermot, Evans Steven, Bradley Martin, Jones Jayne, Peck Robert J, Dube Asha, Rigby Emma, Dalton Ann

Abstract excerpt

OBJECTIVES: Predisposition to alcoholic liver disease (ALD) may be partly genetic. Heterozygosity for the HFE mutations C282Y and/or H63D has been associated with more severe disease in several liver conditions. Studies in ALD have not used controls matched for alcohol consumption and results have been conflicting. METHODS: HFE genotyping was performed in two Caucasian heavy-drinking cohorts (>60 units/wk (M) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Blood Donors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ferritins

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to Liver Diseases, Alcoholic

Share to Transferrin

Source

Identifiers

PMID: 16454835
DOI: 10.1111/j.1572-0241.2006.00439.x

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls.PMID 16454835Read ↗

Hfe mutations and iron overload in patients with alcoholic liver disease.Semantic proximity Read ↗

Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease.Semantic proximity Read ↗

HFE gene mutations in patients with alcoholic liver disease. A prospective study from northwestern Poland.Semantic proximity Read ↗

HFE genotype in patients with hemochromatosis and other liver diseases.Semantic proximity Read ↗

C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease.Semantic proximity Read ↗

Hemochromatosis gene mutations, liver function tests and iron status in alcohol-dependent patients admitted for detoxification.Semantic proximity Read ↗

HFE genetic variability and risk of alcoholic liver disease: A meta-analysis.Semantic proximity Read ↗

Risk of Hepatocellular Carcinoma in Patients with Various HFE Genotypes.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.Semantic proximity Read ↗

HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis.Semantic proximity Read ↗

HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.