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Article

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.

Journal of hepatology - 1 Sept 1999

Bonkovsky H L, Jawaid Q, Tortorelli K, LeClair P, Cobb J, Lambrecht R W, Banner B F

Abstract excerpt

BACKGROUND/AIMS: Non-alcoholic steatohepatitis (NASH) is increasingly recognized, and its pathogenesis is believed to involve increased oxidative stress. Elevated levels of serum ferritin and positive liver iron stains are often observed in patients with NASH, and the pathogenesis of liver injury due to iron is also thought to involve oxidative stress. The aim of this study was to determine whether there is an...

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Source

Identifiers

PMID: 10488699
DOI: 10.1016/s0168-8278(99)80032-4

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.PMID 10488699Read ↗

HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity.Semantic proximity Read ↗

HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis.Semantic proximity Read ↗

The HFE gene heterozygosis H63D: a cofactor for liver damage in patients with steatohepatitis? Epidemiological and clinical considerations.Semantic proximity Read ↗

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis.Semantic proximity Read ↗

Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.Semantic proximity Read ↗

Prevalence of the hemochromatosis gene mutation in patients with nonalcoholic steatohepatitis and correlation with degree of liver fibrosis.Semantic proximity Read ↗

Hfe mutations and iron overload in patients with alcoholic liver disease.Semantic proximity Read ↗

HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma.Semantic proximity Read ↗

Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis.Semantic proximity Read ↗

Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations.Semantic proximity Read ↗

HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls.Semantic proximity Read ↗

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