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Article

HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis.

Journal of hepatology - 1 Mar 2003

Erhardt Andreas, Maschner-Olberg Andrea, Mellenthin Claudia, Kappert Günther, Adams Ortwin, Donner Andreas, Willers Reinhard, Niederau Claus, Häussinger Dieter

Abstract excerpt

BACKGROUND/AIMS: The impact of heterozygous HFE mutations on the course of chronic hepatitis C and iron indices was studied. METHODS: Ferritin, transferrin saturation (TS), serum iron, C282Y and H63D mutations were determined in 401 patients with chronic hepatitis C virus (HCV) infection and 295 healthy controls. Liver histologies were available in 217 and HCV genotypes in 339 patients. RESULTS: Allele...

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Source

Identifiers

PMID: 12586300
DOI: 10.1016/s0168-8278(02)00415-4

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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