Article
Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Nov 2007
Jahangir Tafrechi Roshan S, van de Rijke Frans M, Allallou Amin, Larsson Chatarina, Sloos Willem C R, van de Sande Marchien, Wählby Carolina, Janssen George M C, Raap Anton K
Abstract excerpt
Segregation of mitochondrial DNA (mtDNA) is an important underlying pathogenic factor in mtDNA mutation accumulation in mitochondrial diseases and aging, but the molecular mechanisms of mtDNA segregation are elusive. Lack of high-throughput single-cell mutation load assays lies at the root of the paucity of studies in which, at the single-cell level, mitotic mtDNA segregation patterns have been analyzed. Here we...
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