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Article

Genotypic and phenotypic changes in exhaustively grown cell lines from mitochondrial cytopathy patients.

Muscle & nerve - 1 May 1998

Siregar N C, Jean-François M J, Blok R B, Byrne E

Abstract excerpt

Understanding the pathobiology of mitochondrial (mt) DNA diseases involves both characterization of the effects of individual mutations on respiratory function and elucidation of the changes in mutation load and distribution (energy mosaicism) over serial cell generations. Whether a given mutation is stably maintained, or increases or decreases with cell growth, is one of the determinants as to whether a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9572239
DOI: 10.1002/(sici)1097-4598(199805)21:5<599::aid-mus6>3.0.co;2-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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