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Article

Detection of heteroplasmy in individual mitochondrial particles.

Analytical and bioanalytical chemistry - 1 Aug 2010

Poe Bobby G, Duffy Ciarán F, Greminger Michael A, Nelson Bradley J, Arriaga Edgar A

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations have been associated with disease and aging. Since each cell has thousands of mtDNA copies, clustered into nucleoids of five to ten mtDNA molecules each, determining the effects of a given mtDNA mutation and their connection with disease phenotype is not straightforward. It has been postulated that heteroplasmy (coexistence of mutated and wild-type DNA) follows simple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20467729
DOI: 10.1007/s00216-010-3751-3
PMCID: PMC3035356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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