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Article

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors.

Neoplasia (New York, N.Y.) - 1 Jun 2009

Bruckheimer Elizabeth M, Fazenbaker Christine A, Gallagher Sandra, Mulgrew Kathy, Fuhrmann Stacy, Coffman Karen T, Walsh William, Ready Shannon, Cook Kim, Damschroder Melissa, Kinch Michael, Kiener Peter A, Woods Rob, Gao Changshou, Dall'Acqua William, Wu Herren, Coats Steven

Abstract excerpt

EphA2 is a receptor tyrosine kinase that has been shown to be overexpressed in a variety of human tumor types. Previous studies demonstrated that agonist monoclonal antibodies targeting EphA2 induced the internalization and degradation of the receptor, thereby abolishing its oncogenic effects. In...

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Identifiers

PMID: 19484140
DOI: 10.1593/neo.81578
PMCID: PMC2685440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19484140-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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