Article
Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia.
Leukemia - 1 Oct 2007
Savani B N, Mielke S, Adams S, Uribe M, Rezvani K, Yong A S M, Zeilah J, Kurlander R, Srinivasan R, Childs R, Hensel N, Barrett A J
Abstract excerpt
Natural killer (NK) cells are the first lymphocytes to recover after allogeneic stem cell transplantation (SCT) and can exert powerful graft-versus-leukemia (GVL) effects determining transplant outcome. Conditions governing NK cell alloreactivity and the role of NK recovery in sibling SCT are not well defined. NK cells on day 30 post-transplant (NK30) were measured in 54 SCT recipients with leukemia and donor and...
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