Article
NK-KIR transcript kinetics correlate with acute graft-versus-host disease occurrence after allogeneic bone marrow transplantation.
Human immunology - 1 May 2005
Denis Laure, Gagne Katia, Gueglio Brigitte, Kerdudou Nolwenn, Milpied Noel, Simon Philippe, Follea Gilles, Bonneville Marc, Harousseau Jean-Luc, Bignon Jean-Denis
Abstract excerpt
Natural killer (NK) cell alloreactivity observed during stem cell transplantation (SCT) can be either beneficial (graft-versus-leukemia effect) or detrimental to the host (graft-versus-host disease). Killer immunoglobulin-like receptors (KIRs), expressed on NK and CD8 memory T cells, are regulated at a posttranscriptional level and, because there are currently no KIR-specific antibodies available, the analysis of...
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