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Article

Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma.

American journal of respiratory and critical care medicine - 15 Dec 2007

Salam Muhammad T, Gauderman W James, McConnell Rob, Lin Pi-Chu, Gilliland Frank D

Abstract excerpt

RATIONALE: Transforming growth factor (TGF)-beta1 is involved in airway inflammation and remodeling, two key processes in asthma pathogenesis. Tobacco smoke and traffic emissions induce airway inflammation and modulate TGF-beta1 gene expression. We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures. OBJECTIVES: We tested these hypotheses among 3,023...

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Identifiers

PMID: 17673695
DOI: 10.1164/rccm.200704-561OC
PMCID: PMC2176104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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