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Article

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.

Oncogene - 4 May 2017

Xie X, Kaoud T S, Edupuganti R, Zhang T, Kogawa T, Zhao Y, Chauhan G B, Giannoukos D N, Qi Y, Tripathy D, Wang J, Gray N S, Dalby K N, Bartholomeusz C, Ueno N T

Abstract excerpt

c-Jun N-terminal kinase (JNK) plays a vital role in malignant transformation of different cancers, and JNK is highly activated in basal-like triple-negative breast cancer (TNBC). However, the roles of JNK in regulating cancer stem-like cell (CSC) phenotype and tumorigenesis in TNBC are not well defined. JNK is known to mediate many cellular events via activating c-Jun. Here, we found that JNK regulated c-Jun...

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Identifiers

PMID: 27941886
DOI: 10.1038/onc.2016.417
PMCID: PMC6116358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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