Article
Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD.
Obesity (Silver Spring, Md.) - 1 Oct 2010
Jiang Chao Qiang, Lam Tai Hing, Liu Bin, Lin Jie Ming, Yue Xiao Jun, Jin Ya Li, Cheung Bernard M Y, Thomas G Neil
Abstract excerpt
Interleukin-6 (IL-6) is a key pleiotropic cytokine that modulates the inflammatory response. Single-nucleotide polymorphisms (SNPs) within associated genes may contribute to the metabolic syndrome (MES). We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome. A total of 1,979 older Chinese subjects aged 50-92 years from...
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