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Article

Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Aug 2007

Karlsson Anders, Sauer-Eriksson A Elisabeth

Abstract excerpt

The use of high temperatures in the purification procedures of heat-stable proteins is a well established technique. Recently, rapid pre-heat treatment of protein samples prior to crystallization trials was described as a final polishing step to improve the diffraction properties of crystals [Pusey et al. (2005), Prog. Biophys. Mol. Biol. 88, 359-386]. The present study demonstrates that extended high-temperature...

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Identifiers

PMID: 17671371
DOI: 10.1107/S1744309107033957
PMCID: PMC2335167

Genes

TTR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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