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Article

Analysis of amyloidogenic transthyretin mutations using continuum solvent free energy calculations.

Proteins - 1 Dec 2022

Hartmann Julian, Zacharias Martin

Abstract excerpt

Many proteins can undergo pathological conformational changes that result in the formation of amyloidogenic fibril structures. Various neurodegenerative diseases are associated with such pathological fibril formation of specific proteins. Transthyretin (TTR) is a tetrameric globular transport protein in the blood plasma that can dissociate, unfold, and form long and stable fibrils. Many TTR mutations are known...

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PMID: 35841533
DOI: 10.1002/prot.26399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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