Article
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.
Human molecular genetics - 15 Jul 2009
Fry Andrew E, Ghansa Anita, Small Kerrin S, Palma Alejandro, Auburn Sarah, Diakite Mahamadou, Green Angela, Campino Susana, Teo Yik Y, Clark Taane G, Jeffreys Anna E, Wilson Jonathan, Jallow Muminatou, Sisay-Joof Fatou, Pinder Margaret, Griffiths Michael J, Peshu Norbert, Williams Thomas N, Newton Charles R, Marsh Kevin, Molyneux Malcolm E, Taylor Terrie E, Koram Kwadwo A, Oduro Abraham R, Rogers William O, Rockett Kirk A, Sabeti Pardis C, Kwiatkowski Dominic P
Abstract excerpt
The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a nonsense mutation (T1264G; rs3211938) had undergone recent positive selection in the Yoruba of Nigeria. To investigate the global distribution of this putative...
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