Article
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Transplantation - 27 Jul 2007
Zahorchak Alan F, Kean Leslie S, Tokita Daisuke, Turnquist Heth R, Abe Masanori, Finke Jennifer, Hamby Kelly, Rigby Mark R, Larsen Christian P, Thomson Angus W
Abstract excerpt
BACKGROUND: Immature dendritic cells (DC) can promote long-term transplant survival in rodents. We assessed the impact of stably immature, donor-derived DC on alloimmune reactivity in rhesus macaques. METHODS: CD14 monocytes isolated from leukapheresis products of Macacca mulatta were cultured in granulocyte-macrophage colony stimulating factor plus interleukin (IL)-4+/-vitamin (vit) D3, and IL-10. Major...
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