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Article

IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens.

European journal of immunology - 1 Aug 2006

Lapenta Caterina, Santini Stefano M, Spada Massimo, Donati Simona, Urbani Francesca, Accapezzato Daniele, Franceschini Debora, Andreotti Mauro, Barnaba Vincenzo, Belardelli Filippo

Abstract excerpt

Dendritic cells (DC) generated after a short-term exposure of monocytes to IFN-alpha and GM-CSF (IFN-DC) are highly effective in inducing cross-priming of CD8(+ )T cells against viral antigens. We have investigated the mechanisms responsible for the special attitude of these DC and compared their activity with that of reference DC. Antigen uptake and endosomal processing capabilities were similar for IFN-DC and...

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PMID: 16856207
DOI: 10.1002/eji.200535579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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