Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

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Article

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

Oncogene - 1 Dec 1991

Burns P A, Kemp C J, Gannon J V, Lane D P, Bremner R, Balmain A

Abstract excerpt

Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis of skin tumors induced in F1 hybrids between Mus musculus and Mus spretus mice. The results show...

Topics

Amino Acid Sequence
Animals
Base Sequence
Carcinoma
Cell Line
Codon
Crosses, Genetic
Frameshift Mutation
Genes, p53
Heterozygote
Introns
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Molecular Sequence Data

Muridae

Mutation

Neoplasm Transplantation

Oligodeoxyribonucleotides

Source

Open in PubMed

Identifiers

PMID: 1766680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1766680-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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