Article
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
American journal of human genetics - 1 Dec 2005
Plenge Robert M, Padyukov Leonid, Remmers Elaine F, Purcell Shaun, Lee Annette T, Karlson Elizabeth W, Wolfe Frederick, Kastner Daniel L, Alfredsson Lars, Altshuler David, Gregersen Peter K, Klareskog Lars, Rioux John D
Abstract excerpt
Candidate-gene association studies in rheumatoid arthritis (RA) have lead to encouraging yet apparently inconsistent results. One explanation for the inconsistency is insufficient power to detect modest effects in the context of a low prior probability of a true effect. To overcome this limitation, we selected alleles with an increased probability of a disease association, on the basis of a review of the...
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