Article
A common mitochondrial haplogroup is associated with elevated total serum IgE levels.
The Journal of allergy and clinical immunology - 1 Aug 2007
Raby Benjamin A, Klanderman Barbara, Murphy Amy, Mazza Salvatore, Camargo Carlos A, Silverman Edwin K, Weiss Scott T
Abstract excerpt
BACKGROUND: Maternal history of asthma or atopy is among the most consistently reported risk factors for asthma and atopy in children, yet the molecular basis for this observation remains unclear. Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy. OBJECTIVE: We set out to...
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